The expression of EMX2 lead to cell cycle arrest in glioblastoma cell line
Résumé
Glioblastoma (GB) is a highly invasive primary brain tumor that nearly always systematically recurs at the site of resection despite aggressive radio-chemotherapy. Previously, we reported a gene expression signature related to tumor infiltration. Within this signature, the EMX2 gene encodes a homeodomain transcription factor that we found was down regulated in glioblastoma. As EMX2 is reported to play a role in carcinogenesis, we investigated the impact of EMX2 overexpression in glioma-related cell lines.
Auteurs, date et publication :
Auteurs Annabelle Monnier , Rachel Boniface , Régis Bouvet , Amandine Etcheverry , Marc Aubry , Tony Avril , Véronique Quillien , Eric Chevet , Jean Mosser
Publication : BMC Cancer
Date : 2018
Volume : 18
Issue : 1
Pages : 1213