Integration of transcriptome and proteome profiles in glioblastoma: looking for the missing link
Résumé
Glioblastoma (GB) is the most common and aggressive tumor of the brain. Genotype-based approaches and independent analyses of the transcriptome or the proteome have led to progress in understanding the underlying biology of GB. Joint transcriptome and proteome profiling may reveal new biological insights, and identify pathogenic mechanisms or therapeutic targets for GB therapy. We present a comparison of transcriptome and proteome data from five GB biopsies (TZ) vs their corresponding peritumoral brain zone (PBZ). Omic analyses were performed using RNA microarray chips and the isotope-coded protein label method (ICPL).
Auteurs, date et publication :
Auteurs Jean-Michel Lemée , Anne Clavreul , Marc Aubry , Emmanuelle Com , Marie de Tayrac , Jean Mosser , Philippe Menei
Publication : BMC Molecular Biology
Date : 2018
Volume : 19
Issue : 1
Pages : 13