Auteurs, date et publication :
Auteurs J Roy , C Picon-Cochard , Angela Augusti , Marie-Lise Benot , Lionel Thierry , Olivier Darsonville , Damien Landais , Clément Piel , Marc Defossez , Sebastien Devidal , Escape Christophe , Olivier Ravel , Nathalie Fromin , Florence Volaire , Alexandru Milcu , Michael Bahnh , Jean-François Soussana
Publication : Proceeding of the National Academy of Sciences USA
Date : 2025
Volume : 113
Pages : 6224–6229.
Catégorie(s)
#ANR-Citation #CNRS #Ecotron de MontpellierAuteurs, date et publication :
Auteurs Jessica L. Abbate , Janis Antonovics
Publication : Oikos
Date : 2025
Volume : 123
Issue : 9
Pages : 1126-1136
Catégorie(s)
#CNRS #Lautaret #UGARésumé
Many studies have shown effects of plants species on fungal communities, but these are often confounded with soil effects. Thus, the specific role of plant species in structuring rhizospheric and soil fungal communities is poorly described. Our study used microcosms in which plants were grown under artificial conditions to bridge this gap. Two perennial grasses dominating subalpine grasslands, Festuca paniculata and Dactylis glomerata, were grown at two levels of fertilization on standard soil. Fungal communities were determined by 454 pyrosequencing of the internal transcribed spacer 1 region. Among the fungal communities characterized by the primers used, original communities were associated to each plant species and also diverged between rhizosphere and bulk soils within each plant species, though there were no significant fertilization effects. Differences regarded global composition of the fungal communities and abundant molecular operational taxonomic units (MOTUs). Both plant species and location effects were reflected more in the abundance than in the composition of MOTUs. The observed differences in fungal communities coincide with differing strategies of plant root growth, with D. glomerata having greater root mass, length, and area than F. paniculata. Our study, by dissociating soil effects from plant effects, demonstrated that plant species exert a key control on soil fungi. We suggest that such effects may be linked to inter-specific differences in root traits and their consequences on nitrogen uptake.
Auteurs, date et publication :
Auteurs B. Mouhamadou , J. Puissant , E. Personeni , M. Desclos-Theveniau , E. M. Kastl , M. Schloter , L. Zinger , J. Roy , R. A. Geremia , S. Lavorel
Publication : Biology and Fertility of Soils
Date : 2013
Volume : 49
Issue : 8
Pages : 1131-1139
Catégorie(s)
#CNRS #Lautaret #UGARésumé
BEMEVO : Bio-indication et Effet Mémoire d'une Exposition des Végétaux cultivés à l'Ozone
Auteurs, date et publication :
Auteurs Jean-Jacques Bessoule , Simon Chollet , Amandine Hansart , Marina Le Guedard , Luis Leitao , Juliette Leymarie , Ruben Puga Freitas , Anne Repellin
Date : 2025
Catégorie(s)
#CNRS #Ecotron IleDeFrance #ENSRésumé
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are approved for second-line treatment of EGFR wild-type (EGFR-wt) nonsmall cell lung cancer (NSCLC). However, results from randomised trials performed to compare EGFR-TKIs with chemotherapy in this population did not show any survival benefit. In the era of immunotherapy, many drugs are approved for second-line treatment of EGFR-wt NSCLC and there is a need to reassess the role of EGFR-TKIs in this setting.The Biomarkers France study is a large nationwide cohort of NSCLC patients tested for EGFR mutations. We used this database to collect clinical, biological, treatment and outcome data on EGFR-wt patients who received second-line treatment with either EGFR-TKIs or chemotherapy.Among 1278 patients, 868 received chemotherapy and 410 received an EGFR-TKI. Median overall survival and progression-free survival were longer with chemotherapy than with an EGFR-TKI. Overall survival was 8.38 versus 4.99 months, respectively (hazard ratio 0.70, 95% CI 0.59-0.83; p<0.0001) and progression-free survival was 4.30 versus 2.83 months, respectively (hazard ratio 0.66, 95% CI 0.57-0.77; p<0.0001).This study is helpful to guide a multiline treatment strategy for EGFR-wt NSCLC patients. Immunotherapy is approved for second-line treatment. For third-line treatment, chemotherapy results in longer overall survival and progression-free survival, and should be preferred to EGFR-TKIs.
Auteurs, date et publication :
Auteurs Pascale Tomasini , Solenn Brosseau , Julien Mazières , Jean-Philippe Merlio , Michèle Beau-Faller , Jean Mosser , Marie Wislez , L'Houcine Ouafik , Benjamin Besse , Isabelle Rouquette , Didier Debieuvre , Fabienne Escande , Virginie Westeel , Clarisse Audigier-Valette , Pascale Missy , Alexandra Langlais , Frank Morin , Denis Moro-Sibilot , Gérard Zalcman , Fabrice Barlesi
Publication : The European Respiratory Journal
Date : 2017
Volume : 50
Issue : 2
Pages : 1700514
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Aims In subalpine grasslands, litter decomposition controls soil nutrient availability and is highly sensitive to increasing intensity and frequency of extreme climate events, potentially impacting grasslands diversity and functioning. Here, we assessed the effects of early snowmelt and summer drought on decomposition, and how these were modulated by agricultural management.
Auteurs, date et publication :
Auteurs Lionel Bernard , Arnaud Foulquier , Christiane Gallet , Sandra Lavorel , Jean-Christophe Clément
Publication : Plant and Soil
Date : 2025
Volume : 435
Issue : 1-2
Pages : 225-238
Catégorie(s)
#CNRS #Lautaret #UGARésumé
European mountain grasslands are increasingly affected by land-use changes and climate, which have been suggested to exert important controls on grassland carbon (C) and nitrogen (N) pools. However, so far there has been no synthetic study on whether and how land-use changes and climate interactively affect the partitioning of these pools amongst the different grassland compartments. We analyzed the partitioning of C and N pools of 36 European mountain grasslands differing in land-use and climate with respect to above- and belowground phytomass, litter and topsoil (top 23 cm). We found that a reduction of management intensity and the abandonment of hay meadows and pastures increased above-ground phytomass, root mass and litter as well as their respective C and N pools, concurrently decreasing the fractional contribution of the topsoil to the total organic carbon pool. These changes were strongly driven by the cessation of cutting and grazing, a shift in plant functional groups and a related reduction in litter quality. Across all grasslands studied, variation in the impact of land management on the topsoil N pool and C/N-ratio were mainly explained by soil clay content combined with pH. Across the grasslands, below-ground phytomass as well as phytomass- and litter C concentrations were inversely related to the mean annual temperature; furthermore, C/N-ratios of phytomass and litter increased with decreasing mean annual precipitation. Within the topsoil compartment, C concentrations decreased from colder to warmer sites, and increased with increasing precipitation. Climate generally influenced effects of land use on C and N pools mainly through mean annual temperature and less through mean annual precipitation. We conclude that site-specific conditions need to be considered for understanding the effects of land use and of current and future climate changes on grassland C and N pools.
Auteurs, date et publication :
Auteurs Julia Seeber , Erich Tasser , Dagmar Rubatscher , Ingrid Loacker , Sandra Lavorel , T. Matthew Robson , Manuela Balzarolo , Nuria Altimir , Matthias Drösler , Loris Vescovo , Sonja Gamper , Peter Barančok , Tomasz Staszewski , Georg Wohlfahrt , Alexander Cernusca , M. -Teresa Sebastia , Ulrike Tappeiner , Michael Bahn
Publication : Science of The Total Environment
Date : 2025
Volume : 822
Pages : 153380
Catégorie(s)
#CNRS #Lautaret #UGAAuteurs, date et publication :
Auteurs Lydie Blottière , Mourad Jaffar-Bandjee , Stéphan Jacquet , Alexis Millot , Florence D. Hulot
Publication : Freshwater Biology
Date : 2025
Volume : 62
Issue : 1
Pages : 161-177
Catégorie(s)
#CNRS #ENS #INRAE #OLARésumé
In French subalpine grasslands, cessation of mowing promotes dominance of Festuca paniculata, which alters plant diversity and ecosystem functioning. One of the mechanisms underpinning such effects may be linked to simultaneous changes in the abundance of fungal symbionts such as endophytes and arbuscular mycorrhizal fungi. In field conditions, mowing reduced the abundance of the endophyte Neotyphodium sp. in leaves of F. paniculata by a factor of 6, and increased mycorrhizal densities by a factor of 15 in the soil. In greenhouse experiments, the mycorrhizal colonization of Trifolium pratense and Allium porrum increased 3- fold and 3.8- fold respectively in mown vs unmown grassland soil. Significantly reduced growth of the two host plants was also observed on soil from the unmown grassland. Such opposite effects of mowing on the two functional groups of fungal symbionts could suggest interactions between these two groups, which in turn could contribute to structuring plant communities in subalpine grasslands.
Auteurs, date et publication :
Auteurs M.N. Binet , L. Sage , C. Malan , J.C. Clément , D. Redecker , D. Wipf , R.A. Geremia , S. Lavorel , B. Mouhamadou
Publication : Fungal Ecology
Date : 2025
Volume : 6
Issue : 4
Pages : 248-255
Catégorie(s)
#CNRS #Lautaret #UGAAuteurs, date et publication :
Auteurs Michael Danger , Béatrice Allard , Mohamad B. Arnous , Jean-François Carrias , Jacques Mériguet , Loïc Ten-Hage , Gérard Lacroix
Publication : Hydrobiologia
Date : 2025
Volume : 679
Issue : 1
Pages : 251-266