Résumé
The Publisher regrets that this article is an accidental duplication of an article that has already been published, https://doi.org/10.1016/S0007-4551(18)30393-X. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
Auteurs, date et publication :
Auteurs Alexandra Frelau , Marc Pracht , Samuel Le Sourd , Alexandra Lespagnol , Romain Corre , Cédric Ménard , Karin Tarte , Jean Mosser , Julien Edeline
Publication : Bulletin du Cancer
Date : 2018
Catégorie(s)
#CNRS #EcoGenO #Université de RennesAuteurs, date et publication :
Auteurs Anne-Laure Besnard , Daniel J. Park , Bernard J. Pope , Fleur Hammet , Sophie Michon-Coudouel , Marine Biget , Stacy A. Krueger-Hadfield , Stéphane Mauger , Eric J. Petit
Date : 2023
Catégorie(s)
#CNRS #EcoGenO #Université de RennesAuteurs, date et publication :
Auteurs Olivier Bochet , Lorine Bethencourt , Alexis Dufresne , Julien Farasin , Mathieu Pédrot , Thierry Labasque , Eliot Chatton , Nicolas Lavenant , Christophe Petton , Benjamin W. Abbott , Luc Aquilina , Tanguy Le Borgne
Publication : Nature Geoscience
Date : 2025
Volume : 13
Issue : 2
Pages : 149-155
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Improving feed efficiency (FE) is a major challenge in pig production. This complex trait is characterized by a high variability. Therefore, the identification of predictors of FE may be a relevant strategy to reduce phenotyping efforts in breeding and selection programs. The aim of this study was to investigate the suitability of expressed muscle genes in prediction of FE traits in growing pigs. The approach considered different transcriptomics experiments to cover a large range of FE values and identify reliable predictors.
Auteurs, date et publication :
Auteurs Farouk Messad , Isabelle Louveau , Basile Koffi , Hélène Gilbert , Florence Gondret
Publication : BMC Genomics
Date : 2019
Volume : 20
Issue : 1
Pages : 659
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Considering the plant microbiota, temporal changes are expected depending on plant development stages and environmental pressures because of modifications in plant requirements and available soil microbial reservoir.
Auteurs, date et publication :
Auteurs Marine Biget , Cendrine Mony , Tingting Wang , Ning Ling , Adèle Miteul , Olivier Jambon , Romain Causse-Védrines , Sophie Michon-Coudouel , Maxime Hervé , Véronique Chable , Sabrina Pernet , Philippe Vandenkoornhuyse
Publication : Plant and Soil
Date : 2024
Volume : 494
Issue : 1
Pages : 217-233
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Runt-related transcription factor 1 (RUNX1) is a well-known master regulator of hematopoietic lineages but its mechanisms of action are still not fully understood. Here, we found that RUNX1 localizes on active chromatin together with Far Upstream Binding Protein 1 (FUBP1) in human B-cell precursor lymphoblasts, and that both factors interact in the same transcriptional regulatory complex. RUNX1 and FUBP1 chromatin localization identified c-KIT as a common target gene. We characterized two regulatory regions, at +700 bp and +30 kb within the first intron of c-KIT, bound by both RUNX1 and FUBP1, and that present active histone marks. Based on these regions, we proposed a novel FUBP1 FUSE-like DNA-binding sequence on the +30 kb enhancer. We demonstrated that FUBP1 and RUNX1 cooperate for the regulation of the expression of the oncogene c-KIT. Notably, upregulation of c-KIT expression by FUBP1 and RUNX1 promotes cell proliferation and renders cells more resistant to the c-KIT inhibitor imatinib mesylate, a common therapeutic drug. These results reveal a new mechanism of action of RUNX1 that implicates FUBP1, as a facilitator, to trigger transcriptional regulation of c-KIT and to regulate cell proliferation. Deregulation of this regulatory mechanism may explain some oncogenic function of RUNX1 and FUBP1.
Auteurs, date et publication :
Auteurs Lydie Debaize , Hélène Jakobczyk , Stéphane Avner , Jérémie Gaudichon , Anne-Gaëlle Rio , Aurélien A Sérandour , Lena Dorsheimer , Frédéric Chalmel , Jason S Carroll , Martin Zörnig , Michael A Rieger , Olivier Delalande , Gilles Salbert , Marie-Dominique Galibert , Virginie Gandemer , Marie-Bérengère Troadec
Publication : Nucleic Acids Research
Date : 2018
Volume : 46
Issue : 21
Pages : 11214-11228
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Glioblastoma (GB) is the most common and aggressive tumor of the brain. Genotype-based approaches and independent analyses of the transcriptome or the proteome have led to progress in understanding the underlying biology of GB. Joint transcriptome and proteome profiling may reveal new biological insights, and identify pathogenic mechanisms or therapeutic targets for GB therapy. We present a comparison of transcriptome and proteome data from five GB biopsies (TZ) vs their corresponding peritumoral brain zone (PBZ). Omic analyses were performed using RNA microarray chips and the isotope-coded protein label method (ICPL).
Auteurs, date et publication :
Auteurs Jean-Michel Lemée , Anne Clavreul , Marc Aubry , Emmanuelle Com , Marie de Tayrac , Jean Mosser , Philippe Menei
Publication : BMC Molecular Biology
Date : 2018
Volume : 19
Issue : 1
Pages : 13
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
https://doi.org/10.18632/oncotarget.19171 Anan Yin, Amandine Etcheverry, Yalong He, Marc Aubry, Jill Barnholtz-Sloan, Luhua Zhang, Xinggang Mao, Weijun Chen, Bolin Liu, Wei Zhang, Jean Mosser, Xiang...
Auteurs, date et publication :
Auteurs Anan Yin , Amandine Etcheverry , Yalong He , Marc Aubry , Jill Barnholtz-Sloan , Luhua Zhang , Xinggang Mao , Weijun Chen , Bolin Liu , Wei Zhang , Jean Mosser , Xiang Zhang
Publication : Oncotarget
Date : 2017
Volume : 8
Issue : 52
Pages : 89607-89619
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Abstract
Intestinal organoids are promising tools in the context of animal experiment reduction. Yet, a thorough characterization of the impact of the origin of intestinal stem cells (ISC) on organoid phenotype is needed to routinely use this cellular model. Our objective was to evaluate the effect of ISC donor age on the growth, morphology and cellular composition of intestinal organoids derived from pig, a valuable model of Humans. Organoids were derived from jejunal and colonic ISC obtained from 1, 7, 28, 36 and 180-day old pigs and passaged three times. We first confirmed by qPCR that the expression of 18% of the >80 studied genes related to various intestinal functions differed between jejunal and colonic organoids after two passages (P<0.05). Growth and morphology of organoids depended on intestinal location (greater number and larger organoids derived from colonic than jejunal ISC, P<0.05) but also pig age. Indeed, when ISC were derived from young piglets, the ratio of organoids to spheroids was greater (P<0.05), spheroids were larger during the primary culture but smaller after two passages (P0.05) compared to ISC from older pigs. Finally, no difference in cellular composition, evaluated by immunostaining of markers of the major intestinal cell types (absorptive, enteroendocrine and goblet cells) were observed between organoids originating from 7 or 180-day old pigs, while difference between intestinal site origin were noticed. In conclusion, while the age of the tissue donor affected organoid growth and morphology, it did not influence their phenotype.
Auteurs, date et publication :
Auteurs Camille Duchesne , Gwénaëlle Randuineau , Laurence Le Normand , Véronique Romé , Samia Laraqui , Alexis Pierre Arnaud , Gaëlle Boudry
Date : 2024
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Early nutrition plays a dominant role in infant development and health. It is now understood that the infant diet impacts the gut microbiota and its relationship with gut function and brain development. However, its impact on the microbiota-gut-brain axis has not been studied in an integrative way. The objective here was to evaluate the effects of human milk (HM) or cow’s milk based infant formula (IF) on the relationships between gut microbiota and the collective host intestinal-brain axis. Eighteen 10-day-old Yucatan mini-piglets were fed with HM or IF. Intestinal and fecal microbiota composition, intestinal phenotypic parameters, and the expression of genes involved in several gut and brain functions were determined. Unidimensional analyses were performed, followed by multifactorial analyses to evaluate the relationships among all the variables across the microbiota-gut-brain axis. Compared to IF, HM decreased the α-diversity of colonic and fecal microbiota and modified their composition. Piglets fed HM had a significantly higher ileal and colonic paracellular permeability assessed by
ex vivo
analysis, a lower expression of genes encoding tight junction proteins, and a higher expression of genes encoding pro-inflammatory and anti-inflammatory immune activity. In addition, the expression of genes involved in endocrine function, tryptophan metabolism and nutrient transport was modified mostly in the colon. These diet-induced intestinal modifications were associated with changes in the brain tissue expression of genes encoding the blood-brain barrier, endocrine function and short chain fatty acid receptors, mostly in hypothalamic and striatal areas. The integrative approach underlined specific groups of bacteria (Veillonellaceae, Enterobacteriaceae, Lachnospiraceae, Rikenellaceae, and Prevotellaceae) associated with changes in the gut-brain axis. There is a clear influence of the infant diet, even over a short dietary intervention period, on establishment of the microbiota-gut-brain axis.
Auteurs, date et publication :
Auteurs Elise Charton , Alexandre Bourgeois , Amandine Bellanger , Yann Le-Gouar , Patrice Dahirel , Véronique Romé , Gwenaelle Randuineau , Armelle Cahu , Paul J. Moughan , Carlos A. Montoya , Sophie Blat , Didier Dupont , Amélie Deglaire , Isabelle Le Huërou-Luron
Publication : Frontiers in Nutrition
Date : 2022
Volume : 9
Pages : 976042