Résumé
Due to the importance of arbuscular mycorrhizal fungi (AMF) in ecosystem productivity, a key ecological question is how do their communities assemble? As plant spatial patterns constitute a mosaic of AM fungi habitats, we hypothesized that AM fungal community assembly is determined by plant community structure, both in space and time. We tested our hypothesis by sampling individuals of two host-plant species, Brachypodium pinnatum and Elytrigia repens, from experimental communities cultivated in mesocosms, and assessed their AM fungal root colonizers by mass sequencing. We related AM fungal community structure to the distribution of neighbouring plant species at different spatio-temporal scales. We demonstrated that AM fungal community assembly depends mostly on past plant spatial patterns at a small spatial scale (5 cm), indicating that plants growing at given locations leave a footprint on the AM fungi community. This spatial scale of response was also influenced by the host-plant species, probably by its clonal propagation. Synthesis. Overall, we highlighted that processes involved in Arbuscular mycorrhizal (AM) fungal community assembly do not operate at the rough scale of the overall plant community mosaic but are instead locally determined, delineating the AM fungal ‘eye-view’ of the host-plant community.
Auteurs, date et publication :
Auteurs Anne-Kristel Bittebiere , Philippe Vandenkoornhuyse , Elodie Maluenda , Agnès Gareil , Alexandra Dheilly , Sophie Coudouel , Mathieu Bahin , Cendrine Mony
Publication : Journal of Ecology
Date : 2025
Volume : 108
Issue : 2
Pages : 546-560
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
The Publisher regrets that this article is an accidental duplication of an article that has already been published, https://doi.org/10.1016/S0007-4551(18)30393-X. The duplicate article has therefore been withdrawn. The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal.
Auteurs, date et publication :
Auteurs Alexandra Frelau , Marc Pracht , Samuel Le Sourd , Alexandra Lespagnol , Romain Corre , Cédric Ménard , Karin Tarte , Jean Mosser , Julien Edeline
Publication : Bulletin du Cancer
Date : 2018
Catégorie(s)
#CNRS #EcoGenO #Université de RennesAuteurs, date et publication :
Auteurs Anne-Laure Besnard , Daniel J. Park , Bernard J. Pope , Fleur Hammet , Sophie Michon-Coudouel , Marine Biget , Stacy A. Krueger-Hadfield , Stéphane Mauger , Eric J. Petit
Date : 2023
Catégorie(s)
#CNRS #EcoGenO #Université de RennesAuteurs, date et publication :
Auteurs Olivier Bochet , Lorine Bethencourt , Alexis Dufresne , Julien Farasin , Mathieu Pédrot , Thierry Labasque , Eliot Chatton , Nicolas Lavenant , Christophe Petton , Benjamin W. Abbott , Luc Aquilina , Tanguy Le Borgne
Publication : Nature Geoscience
Date : 2025
Volume : 13
Issue : 2
Pages : 149-155
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Improving feed efficiency (FE) is a major challenge in pig production. This complex trait is characterized by a high variability. Therefore, the identification of predictors of FE may be a relevant strategy to reduce phenotyping efforts in breeding and selection programs. The aim of this study was to investigate the suitability of expressed muscle genes in prediction of FE traits in growing pigs. The approach considered different transcriptomics experiments to cover a large range of FE values and identify reliable predictors.
Auteurs, date et publication :
Auteurs Farouk Messad , Isabelle Louveau , Basile Koffi , Hélène Gilbert , Florence Gondret
Publication : BMC Genomics
Date : 2019
Volume : 20
Issue : 1
Pages : 659
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Considering the plant microbiota, temporal changes are expected depending on plant development stages and environmental pressures because of modifications in plant requirements and available soil microbial reservoir.
Auteurs, date et publication :
Auteurs Marine Biget , Cendrine Mony , Tingting Wang , Ning Ling , Adèle Miteul , Olivier Jambon , Romain Causse-Védrines , Sophie Michon-Coudouel , Maxime Hervé , Véronique Chable , Sabrina Pernet , Philippe Vandenkoornhuyse
Publication : Plant and Soil
Date : 2024
Volume : 494
Issue : 1
Pages : 217-233
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Runt-related transcription factor 1 (RUNX1) is a well-known master regulator of hematopoietic lineages but its mechanisms of action are still not fully understood. Here, we found that RUNX1 localizes on active chromatin together with Far Upstream Binding Protein 1 (FUBP1) in human B-cell precursor lymphoblasts, and that both factors interact in the same transcriptional regulatory complex. RUNX1 and FUBP1 chromatin localization identified c-KIT as a common target gene. We characterized two regulatory regions, at +700 bp and +30 kb within the first intron of c-KIT, bound by both RUNX1 and FUBP1, and that present active histone marks. Based on these regions, we proposed a novel FUBP1 FUSE-like DNA-binding sequence on the +30 kb enhancer. We demonstrated that FUBP1 and RUNX1 cooperate for the regulation of the expression of the oncogene c-KIT. Notably, upregulation of c-KIT expression by FUBP1 and RUNX1 promotes cell proliferation and renders cells more resistant to the c-KIT inhibitor imatinib mesylate, a common therapeutic drug. These results reveal a new mechanism of action of RUNX1 that implicates FUBP1, as a facilitator, to trigger transcriptional regulation of c-KIT and to regulate cell proliferation. Deregulation of this regulatory mechanism may explain some oncogenic function of RUNX1 and FUBP1.
Auteurs, date et publication :
Auteurs Lydie Debaize , Hélène Jakobczyk , Stéphane Avner , Jérémie Gaudichon , Anne-Gaëlle Rio , Aurélien A Sérandour , Lena Dorsheimer , Frédéric Chalmel , Jason S Carroll , Martin Zörnig , Michael A Rieger , Olivier Delalande , Gilles Salbert , Marie-Dominique Galibert , Virginie Gandemer , Marie-Bérengère Troadec
Publication : Nucleic Acids Research
Date : 2018
Volume : 46
Issue : 21
Pages : 11214-11228
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Glioblastoma (GB) is the most common and aggressive tumor of the brain. Genotype-based approaches and independent analyses of the transcriptome or the proteome have led to progress in understanding the underlying biology of GB. Joint transcriptome and proteome profiling may reveal new biological insights, and identify pathogenic mechanisms or therapeutic targets for GB therapy. We present a comparison of transcriptome and proteome data from five GB biopsies (TZ) vs their corresponding peritumoral brain zone (PBZ). Omic analyses were performed using RNA microarray chips and the isotope-coded protein label method (ICPL).
Auteurs, date et publication :
Auteurs Jean-Michel Lemée , Anne Clavreul , Marc Aubry , Emmanuelle Com , Marie de Tayrac , Jean Mosser , Philippe Menei
Publication : BMC Molecular Biology
Date : 2018
Volume : 19
Issue : 1
Pages : 13
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
https://doi.org/10.18632/oncotarget.19171 Anan Yin, Amandine Etcheverry, Yalong He, Marc Aubry, Jill Barnholtz-Sloan, Luhua Zhang, Xinggang Mao, Weijun Chen, Bolin Liu, Wei Zhang, Jean Mosser, Xiang...
Auteurs, date et publication :
Auteurs Anan Yin , Amandine Etcheverry , Yalong He , Marc Aubry , Jill Barnholtz-Sloan , Luhua Zhang , Xinggang Mao , Weijun Chen , Bolin Liu , Wei Zhang , Jean Mosser , Xiang Zhang
Publication : Oncotarget
Date : 2017
Volume : 8
Issue : 52
Pages : 89607-89619
Catégorie(s)
#CNRS #EcoGenO #Université de RennesRésumé
Abstract
Intestinal organoids are promising tools in the context of animal experiment reduction. Yet, a thorough characterization of the impact of the origin of intestinal stem cells (ISC) on organoid phenotype is needed to routinely use this cellular model. Our objective was to evaluate the effect of ISC donor age on the growth, morphology and cellular composition of intestinal organoids derived from pig, a valuable model of Humans. Organoids were derived from jejunal and colonic ISC obtained from 1, 7, 28, 36 and 180-day old pigs and passaged three times. We first confirmed by qPCR that the expression of 18% of the >80 studied genes related to various intestinal functions differed between jejunal and colonic organoids after two passages (P<0.05). Growth and morphology of organoids depended on intestinal location (greater number and larger organoids derived from colonic than jejunal ISC, P<0.05) but also pig age. Indeed, when ISC were derived from young piglets, the ratio of organoids to spheroids was greater (P<0.05), spheroids were larger during the primary culture but smaller after two passages (P0.05) compared to ISC from older pigs. Finally, no difference in cellular composition, evaluated by immunostaining of markers of the major intestinal cell types (absorptive, enteroendocrine and goblet cells) were observed between organoids originating from 7 or 180-day old pigs, while difference between intestinal site origin were noticed. In conclusion, while the age of the tissue donor affected organoid growth and morphology, it did not influence their phenotype.
Auteurs, date et publication :
Auteurs Camille Duchesne , Gwénaëlle Randuineau , Laurence Le Normand , Véronique Romé , Samia Laraqui , Alexis Pierre Arnaud , Gaëlle Boudry
Date : 2024